When will you Click?

Shona Patton

Click chemistry reactions are reactions between an alkyne-tagged molecule and an azide-tagged molecule which use copper as a catalyst. This was introduced by K. B. Sharpless in 2001 for which he was awarded half of the 2001 Nobel Prize in Chemistry. Sharpless developed these reactions in The Scripps Institute, California and has continued developing more reactions since.

Image of the Nobel Prize medal

Nobel Medal

The ultimate goal of click chemistry reactions is to work reliably in small and large scale applications. For a reaction to be defined as a click chemistry reaction it must be modular, efficient, and generate only by-products that can be easily removed. Most reactions are also very simple and use readily available reagents.


So, what exactly can click chemistry be used for?


The applications for using click chemistry is rapidly expanding any many areas, most of all drug discovery. The applications are endless:


  • Organic synthesis of 1, 4-substituted triazoles
  • Peptide modification
  • Modification of natural products and pharmaceuticals
  • Biomedical research, ranging from lead discovery and optimization, to tagging of biological systems, such as proteins, nucleotides and whole organisms.
  • Macrocyclisations using Cu (I) catalysed triazole couplings
  • Modification of DNA and nucleotides
  • Supramolecular chemistry
  • Dendrimer design
  • Carbohydrate clusters and carbohydrate conjugation
  • Polymers
  • Nanotechnology
  • Bio-conjugation


What does this mean for you?


We supply a wide variety of click chemistry reagents, suitable for every application, including azide compounds, alkyne compounds, agarose resins, fluorescent labels and many more.


All of our products can be found here

We are happy to give guidance on what products would best suit your research.


Have you clicked yet?




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