An amine-reactive, non-activated reagent with hydrophilic PEG4 spacer arm.
Alkyne-PEG4-Acid is a polyethylene glycol-containing reagent with a terminal carboxylic acid (–COOH) that can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) forming a stable amide bond. The terminal alkyne group reacts with azides by a mechanism known as the Cu-catalysed click reaction enabling efficient and specific conjugation of derivatised molecules in biological samples.
DMF, DMSO, DCM, THF, Chloroform
Colourless to slightly yellow oil