An activated bis-alkylating reagent with hydrophilic PEG4 spacer arm.
Bis-sulfone-PEG4-NHS ester is a unique heterobifunctional crosslinker with amine and sulfhydryl/thiol reactivity that overcomes the drawbacks associated with the use of traditional sulfhydryl labelling chemistry. Traditional sulfhydryl labelling chemistry cleaves disulfide bridges and leaves them in “open form”, which may compromise the stability and function of an antibody or other proteins. Bis-sulfone reagents re-bridge the disulfide bond, and enhance the structural stability of the protein.
DMF, DMSO, DCM, THF, Chloroform
Oil to amorphous solid