A water-soluble, tetrazine-activated NIR probe.
Methyltetrazine-activated Cy7 dye that reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require a Cu-catalyst or elevated temperatures. The Inverse-Electron Demand Diels-Alder cyclo-addition reaction of TCO with tetrazines is a bio-orthogonal reaction that possesses exceptional kinetics (k > 800 -1 s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bio-orthogonal reaction pair described to date.
Alexa Fluor® 750, Atto™ 750RD, CF™ 750 Dye, DyLight™ 750
Water, DMF, DMSO, MeOH
Dark green solid