An amine-reactive, non-activated building block with enhanced stability and water solubility.
Methyltetrazine-PEG4-Acid is one of the most stable tetrazines commercially available. In addition to stabilisation provided by the electron donating methyl group, the electron donating alkoxy substituent on the aromatic ring further improves the stability of Methyltetrazine-PEG4-Acid. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
DMF, DMSO, DCM, THF, Chloroform