An alkyne-containing metabolic glycoprotein labelling reagent that can be incorporated into the sialic acid biosynthesis pathway.
N-(4-pentynoyl)-mannosamine-tetraacylated (Ac4ManNAl) provides the first part of a simple and robust two-step technique that helps identify and characterise cell surface sialic acid-containing glycoproteins. The alkyne-modified protein is detected with either fluorescent azides or biotin azide. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
DMSO, DMF, DCM, THF, Chloroform
White to grey amorphous solid
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.