Widely used, water-insoluble ligands for copper-catalysed azide-alkyne cyclo-additions.
TBTA was introduced shortly after the copper-catalysed azide-alkyne cyclo-addition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.
DMSO, DMF, DCM, THF, Chloroform
Off-white to grey solid