An amine-reactive, cyclooctene-containing building block.
TCO-PNB Ester is an amine-reactive building block used for modification of amine-containing molecules in organic media. TCO-PNB Ester is supplied as a single axial (major) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.
Important Product Information:
TCO-PNB Ester is not recommended for labelling of proteins in aqueous buffers due to poor level of activation of labelled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester and TCO-PEG12-NHS Ester are well suited for protein and antibody labelling in aqueous buffers.
DMF, DMSO, THF, DCM, Chloroform
White to slightly grey solid